Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence.

We hypothesized that the administration of the superoxide dismutase (SOD) mimetic Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) may reverse diabetes-induced erectile dysfunction. To test this hypothesis, reactive oxygen species-related genes (SOD1, SOD2, GP x 1, CAT, NOS2, NOS3) were tested, erectile functional studies and immunohistochemical analysis were carried out in diabetic rats treated with or without Tempol. Thirty Sprague-Dawley (3-4 months old) rats were divided into three groups (n=10 each), 20 with diabetes (diabetic control and Tempol treatment) and 10 healthy controls. At 12 weeks after the induction of diabetes by streptozotocin and Tempol treatment, all groups underwent in vivo cavernous nerve stimulation. Rat crura were harvested and the expression of antioxidative defense enzymes were examined by semi-quantitative reverse transcriptase PCR (RT-PCR). To confirm the RT-PCR results, we carried out immunohistochemistry (IHC) for catalase (CAT) and iNOS (NOS2). Nitration of tyrosine groups in proteins was also examined by IHC. Mean intracavernous pressure in the diabetic group was significantly lower than in the healthy controls (P <0.001) and was reversed by Tempol treatment (P <0.0108). NOS2 protein expression was significantly increased in diabetic animals compared with healthy controls and Tempol restored NOS2 protein level. Nitrotyrosine was also higher in diabetic animals and although Tempol treatment decreased its formation, it remained higher than that found in healthy controls. This study suggests that Tempol treatment increased erectile function through modulating oxidative stress-related genes in diabetic rats. This is the first report about the relationship between diabetes-induced erectile dysfunction and oxidative stress, and antioxidative therapy using the superoxide dismutase mimetic, Tempol, to restore erectile function

The Earth Effect in the MSW Analysis of the Solar Neutrino Experiments

We consider the Earth effect in the MSW analysis of the Homestake, Kamiokande, GALLEX, and SAGE solar neutrino experiments. Using the time-averaged data and assuming two-flavor oscillations, the large-angle region of the combined fit extends to much smaller angles (to $\sin^22\theta \simeq 0.1$) than when the Earth effect is ignored. However, the additional constraint from the Kamiokande II day-night data excludes most of the parameter space sensitive to the Earth effect independent of astrophysical uncertainties, and leaves only a small large-angle region close to maximal mixing at 90\% C.L. The nonadiabatic solution remains unaffected by the Earth effect and is still preferred. Both theoretical and experimental uncertainties are included in the analysis.Comment: (11 pages, Revtex 3.0 (can be changed to Latex), 3 postscript figures included, UPR-0570T

A Common Explanation for the Atmospheric, Solar-Neutrino and Double Beta Decay Anomalies

We make a number of small changes, including correcting an error in our heavy-neutrino decay rate. None of our analysis is changed, either in substance or detail.Comment: 25 pages, 6 Figures, McGill-93/1

Oscillations of Pseudo-Dirac Neutrinos and the Solar Neutrino Problem

The oscillations of pseudo-Dirac neutrinos in matter are discussed and applied to the solar neutrino problem. Several scenarios such as both $\nu_e$ and $\nu_{\mu}$ being pseudo-Dirac and only $\nu_e$ or $\nu_{\mu}$ being pseudo-Dirac are examined. It is shown that the allowed region in the mass-mixing angle parameter space obtained by comparing the solar neutrino data with the calculations based on the standard solar model and the MSW effect is not unique. The results depend on the nature of neutrinos; for example, if both $\nu_e$ and $\nu_{\mu}$ are pseudo-Dirac, the allowed region determined by the current solar neutrino data does not overlap with that obtained in the usual case of pure Dirac or Majorana neutrinos.Comment: 12 pages, 2 figures (not included

Current Status of the Solar Neutrino Problem with Super-Kamiokande

We perform an updated model-independent analysis using the latest solar neutrino data obtained by $^{37}$Cl and $^{71}$Ga radiochemical experiments, and most notably by a large water-Cherenkov detector SuperKamiokande with their 504 days of data taking. We confirm that the astrophysical solutions to the solar neutrino problem are extremely disfavored by the data and a low-temperature modification of the standard solar model is excluded by more than 5 $\sigma$. We also propose a new way of illuminating the suppression pattern of various solar neutrino flux without invoking detailed flavor conversion mechanisms. It indicates that the strong suppression of $^7$Be neutrinos is no more true when the neutrino flavor conversion is taken into account.Comment: RevTex file, 10 pages, 7 postscript figure

Solar Neutrinos: Radiative Corrections in Neutrino-Electron Scattering Experiments

Radiative corrections to the electron recoil-energy spectra and to total cross sections are computed for neutrino-electron scattering by solar neutrinos. Radiative corrections change monotonically the electron recoil spectrum for incident \b8 neutrinos, with the relative probability of observing recoil electrons being reduced by about 4 \% at the highest electron energies. For $p-p$ and \be7 neutrinos, the recoil spectra are not affected significantly. Total cross sections for solar neutrino-electron scattering are reduced by about 2 \% compared to previously computed values. We also calculate the recoil spectra from $^{13}$N and $^{15}$O neutrinos including radiative corrections.Comment: 40 pages, uuencoded, Z-compress file

Energy-dependent solar neutrino flux depletion in the Exact Parity Model and implications for SNO, SuperKamiokande and BOREXINO

Energy-dependent solar neutrino flux reduction caused by the Mikheyev-Smirnov-Wolfenstein (MSW) effect is applied to the Exact Parity Model. Several scenarios are possible, depending on the region of parameter space chosen. The interplay between intergenerational MSW transitions and vacuum ``intragenerational'' ordinary-mirror neutrino oscillations is discussed. Expectations for the ratio of charged to neutral current event rates at the Sudbury Neutrino Observatory (SNO) are estimated. The implications of the various scenarios for the Boron neutrino energy spectrum and BOREXINO are briefly discussed. The consequences of MSW-induced solar neutrino depletion within the Exact Parity Model differ in interesting ways from the standard $\nu_e - \nu_{\mu, \tau}$ and $\nu_e - \nu_s$ cases. The physical causes of these differences are determined.Comment: 43 pages, 8 figures, RevTeX; to appear in Phys. Rev. D, accepted versio